Endothelin receptor antagonist TAK-044 arrests and reverses the development of carbon tetrachloride-induced cirrhosis in rats. GPx, which are integral part of the cellular antioxidant defense mechanism (Yu, 1994), were lower in aHSCs than in qHSCs. While their activities increased in superoxide-challenged qHSCs, no such effect was observed in aHSCs (Table 2). TABLE 2 Effect of […]