Quantitative RT-PCR analysis revealed increased expression of these p53 genes in the transcription level (Fig. mediates the association between MDMX and MDM2 (6, 7). Genetic studies have shown that like MDM2, MDMX is definitely another essential bad regulator of p53 (8C10). Although it remains unclear why both MDM2 and MDMX are required for p53 control, […]