Caspase-1 becomes activated in response to specific NLRP3 agonists, which results in the processing of pro-IL-1 into its mature secreted form. to include IgG-Ova immune complexes results in the suppression of CFA-induced Th17 responses and a concurrent enhancement of Ova-specific Th2 responses. Furthermore, we show the mechanism by which these immune complexes suppress Th17 responses […]