Using the MEK1/2 inhibitor, U0126 and stably transfected shERK1 and shERK2 MM cell lines, we show that inhibition of both ERK1 and 2 sensitizes MM cells to Dox. Results U0126 significantly modulated endogenous expression of several important drug resistance ( em BCL2, ABCB1, ABCC3 /em ), prosurvival ( em BCL2 /em ), DNA repair ( […]