All the structural figures were prepared using PyMol (The PyMol Molecular Graphics System, Version 1.3, Schr?dinger, LLC). H/D-ex MS (hydrogen-deuterium exchange mass spectrometry) assay. Hydrogen-deuterium exchange experiments were performed using the in-house deuterium exchange system48,49. movement increases heterodimerization stability and transcriptional activity. Our findings show that despite binding to the same HIF-2 PAS-B pocket, ligands […]