This raises the question as to under what conditions a cAMP-mediated Epac-dependent inhibition of vascular KATP channel activity would occur. protein kinase (PKA) (Beavo & Brunton, 2002). Two isoforms of Epac are known to exist: the ubiquitously expressed Epac1 (also known as cAMP-GEFI) and the closely related Epac2 (cAMP-GEFII) (de Rooij 1998; Kawasaki 1998). These […]