Previous studies have shown that this ATP-dependent conformational change leading to closure of the CCT complex also results in its protection against proteinase K?digestion (Meyer et?al., 2003). preventing malignant development (Vousden and Prives, 2009), functioning primarily as a transcription factor to regulate the expression of a large number of genes that induce cellular responses such […]
Notably, using both surgical denervation and the neuromuscular disease amyotrophic lateral sclerosis (ALS) model, we found that elevated levels of HDAC4 are required for efficient repression of MEF2-dependent structural gene expression, indicating a link between the pathological induction of HDAC4 and subsequent MEF2 target gene suppression
Notably, using both surgical denervation and the neuromuscular disease amyotrophic lateral sclerosis (ALS) model, we found that elevated levels of HDAC4 are required for efficient repression of MEF2-dependent structural gene expression, indicating a link between the pathological induction of HDAC4 and subsequent MEF2 target gene suppression. expression of HDAC4 in muscle mass fibers is sufficient […]