(a) General structure of the human being HRF dimer. (e.g., histamine, serotonin) and proteins inflammatory mediators (e.g., proteases, tumor necrosis element (TNF)), and de novo synthesize and secrete arachidonic acid-derived lipids, cytokines, chemokines, and development elements [2,3]. These elements promote type 2 swelling in sensitive individuals. With this review, we will discuss histamine-releasing element (HRF)-mediated […]