Recently, a chimeric antigen receptor T-cell approach was shown to be effective in targeting the thymic stromal lymphopoietic receptor (TLSPR).42 Like 5T4, TLSPR is expressed primarily by malignant subclones that persist after therapy. preferentially localized to bone marrow and displayed the ability to reconstitute the original clonal composition on limited dilution engraftment. Treatment with A1mcMMAF […]