Immunoglobulins bound to transfected cells were detected by flow cytometry. FcRs mediate phagocytosis of IgG-coated pathogens GSK2110183 analog 1 and promote activation of effector cells, leading to inflammatory responses and antibody-mediated cellular cytotoxicity (ADCC; refs.1and2). One FcRII isoform, called FcRIIb, transmits inhibitory signals that promote the maintenance of peripheral tolerance, increase the threshold of activation […]