However, while ADCC activity against CE1176.A3 was significantly improved by IgG3, particularly for PGT151, 10E8v4, 3BNC117 and VRC01 (Supplementary Figure3F), this was not true of 246.F3.C10.2 or BJOX002000.03.2, where mixed isotype-driven effects were observed. To understand epitope effects, we assessed the effect BAY 293 BAY 293 of IgG3 variant for each bNAb pair, represented as […]