To study the mechanisms of E2, estrogen receptor (ER) inhibitor Methyl-piperidino-pyrazole (MPP, Sigma-Aldrich, 100g/kg), Sirt1 siRNA (OriGene Technologies) was given respectively. of MMP-9 were detected. == Results == Hyperglycemia enhanced HE and deteriorated neurological deficits after ICH coming from 6 hours after ICH. E2 treatment prevented BBB disruption and improved neurological deficits twenty four hours […]