Since DM-C showed strong systemic antibody reactions against the homologous PR8, ELISA was performed against various strains belonging to the H1N1 subtype. despite IFI16 the lack of detectable neutralizing antibodies, the vaccination offered heterosubtypic safety against the lethal challenge with the viruses. Sterile safety was confirmed by the complete absence of viral titers in the […]
The elimination half-lives range from 1
The elimination half-lives range from 1.6?days (Nb100) to 7.6?days (Nb75), which correspond to approximately (S)-(-)-5-Fluorowillardiine 771-fold improvement compared to the control Nb (Figures 4B and 4C; Data S2). (NbHSA) that can be readily fused to small biologics for half-life extension. We characterized the thermostability, binding kinetics, and cross-species reactivity of NbHSAs, mapped their epitopes, and […]