This affects highly abundant proteins and produces characteristic peptide ladders usually, which leads to high coverage from the protein by peptides of varied lengths (Fig.?1while true HLA ligands are colored and ligand distribution set for each proteins (for every target peptide (p) as the amount of HLA class I peptides (q) that are assigned towards […]
mAbs that are non-immunogenic in humans induce severe anaphylaxis in existing guinea-pig anaphylaxis models
mAbs that are non-immunogenic in humans induce severe anaphylaxis in existing guinea-pig anaphylaxis models.117 Animals models that are more relevant and in silico and in vitro assessments for predicting immunogenicity/hypersensitivity of mAbs were discussed previously. immune system (dendritic cell) activation and immunogenicity in humans are also described. The importance of selecting a relevant and sensitive […]
We found that adult retinal axons have a lower ratio of GM1/GD1a gangliosides on their surface than DRG axons
We found that adult retinal axons have a lower ratio of GM1/GD1a gangliosides on their surface than DRG axons. absence of eCa2+ on Neu3 sialidase activity and axonal regeneration, cultures were incubated with normal growth media devoid of CaCl2, 30 min before axotomy. siRNA transfection Dissociated DRGs were transfected with siRNA 48 h after plating. […]