J Endocrinol 205: 97C106, 2010 [PubMed] [Google Scholar] 8. p53 build up) and improved the deacetylation of p53 at a SIRT1-targeted site. The reduction in p53 great quantity due to metformin was abolished by inhibition of murine dual tiny 2 (MDM2), a ubiquitin ligase that mediates p53 degradation, aswell as by overexpression of the dominant-negative […]
HeLa APPswe cells treated with DMSO (Panel i) or 10 M -secretase inhibitor IV (Panel j)
HeLa APPswe cells treated with DMSO (Panel i) or 10 M -secretase inhibitor IV (Panel j). spectrometry, using several different BACE1 inhibitors. Besides the expected reductions in A1-40 and A1-42, treatment also changed the relative levels of several other A isoforms. In particular A1-34 decreased, while A5-40 improved, and these changes were more sensitive to […]