S1C). and in thePpt1-KO mice, phosphorylated-S6K-1 (p-S6K1) levels, which Monastrol inversely correlate with lifespan, are markedly elevated. Most importantly, resveratrol (RSV), an antioxidant polyphenol, elevated the NAD+/NADH ratio, levels of ATP, p-AMPK, PGC-1 and SIRT1 while decreasing the level of p-S6K1 in both INCL fibroblasts and inPpt1-KO mice, which showed a modest increase in lifespan. […]